Study Shows Drugs Like Aleve, Ibuprofen Might Be Making Arthritis Inflammation Worse

  • Johanna Luitjens, the study’s lead author, is a postdoctoral scholar in the Department of Radiology and Biomedical Imaging at the University of California San Francisco.
  • Luitjens pointed out a few potential reasons for the findings, noting that “the anti-inflammatory effect that normally comes from NSAIDs may not effectively prevent synovitis, with progressive degenerative change resulting in worsening of synovitis over time.” Synovitis occurs when tissue around a joint becomes inflamed. 
  • She also pointed out that those who take the drugs might have an increased level of physical activity because their pain subsides, “which could potentially lead to worsening of synovitis, although we adjusted for physical activity in our model.”