- Vance repeatedly asserted that Ryan, as Democrat House member, has voted with Speaker Nancy Pelosi “100% of the time.”
- Ryan used a line similar to the scripted one he used in the first debate about Vance “kissed his ass,” referring to his rival having sought former President Trump endorsement in the GOP primary.
- Each candidate in the debate was asked to highlight an issue on which they disagreed with party leaders: Vance pointed to Trump’s appointment of former National Security Advisor John Bolton, and Ryan pointed out that he once challenged Pelosi for the speakership.